Behaviour disorder in monosomy 10qter.

Monosomy 18p

Monosomy 18p refers to a chromosomal disorder resulting from the deletion of all or part of the short arm of chromosome 18. The incidence is estimated to be about 1:50,000 live-born infants. In the commonest form of the disorder, the dysmorphic syndrome is very moderate and non-specific. The main clinical features are short stature, round face with short philtrum, palpebral ptosis and large ear...

Rapid eye movement behaviour disorder.

A 70-year-old man was referred to a specialist sleep service in December 2010 by his general practitioner at the prompting of his wife. He reported a 7–8-year history of near-nightly, increasingly severe sleep disturbance with vivid dreams which would occur in the latter half of the night. Bedclothes were often found strewn around the room, and he would wake in unusual positions. The dreams usu...

Personality Disorder and Criminal Behaviour

Purpose of review: There is a well established association between personality disorder and offending but the nature of the relationship is less well understood. We reviewed the recent literature on personality disorder and offending, picking out studies that examined the relationship between the two. Recent findings: Cluster A, B and C personality disorders are each associated with different t...

Suicidal Behaviour in Obsessive Compulsive Disorder Patients

Loss of heterozygosity for 10q22-10qter in malignant melanoma progression.

Karyotypic and molecular data indicate that genetic events involving the chromosome region 10q22-10qter may be related to tumorigenesis in malignant melanoma. To test this we analyzed 10 polymorphic microsatellite repeats in the region 10q22-qter, using a polymerase chain reaction-based assay for loss of heterozygosity and DNA isolated from normal and tumor tissue from 26 individuals with malig...